Nanogel's POWER (una curvatura da Scienze)

A new way to fight the Alzheimer.


Similarly to what happens to diabetic patients, patients affected by Alzheimer disease, known also as "Type 3 Diabetes", develop a resistance against cerebral insuline. This condition is considereted a risk factor leading to desease. The hormone, used in an experimental therapy, is expected to improve cognitive abilities in patients affected by Alzheimer, by blocking the neurodegeneration. A recent research coordinated by the Biomedic and Molecular Immunology Istitute of IBIM-CNR (Palermo), published on "Biomaterials", pathed the way to engineered polymer nanogels, able to deliver insuline to the brain,which avoids the side effects of traditional treatments. IBF-CNR and the Departments of Chemical Engineering, Industrial Engineering, Mananging Engineering, Computer Science Engineering, Mechanical Engineering and the Departments of Physics and Chemistry of the University of Palermo contribuited to the development of these nanogels.

"Administration of insuline on a regular basis, used in diabetic therapy, is a risk for the onset of increased hypoglycemia, and  resistance to insuline itself. Therefore we created nanogels which are able to incorporate, protect and deliver insuline directly to the brain (NG-IN)", explained Marta Di Carlo of IBIM-CNR. "The research team produced these nanosystems for the preparation of a rhinal-spray. This way of administration is an altenative strategy to get over the hematoencephalic barrier and to arrive quickly to the brain, through the olfactory mucosa, bypassing the peripheral districts, where it could produce side effects".
 
According to NG-IN scientists, nanogels are a promising candidate for the development of an innovative therapy for Alzheimer. "Nanogels, small hydropholic crosslinked polymer particles, were produced by an innovative process which use ionising radiation created by an electron accelerator, commonly used for industrial sterilisation of biomedical devices", specified the reseacher. "Thus, starting by an aqueous solution of a biocompatible polymer, without resorting to the use of organic solvents and surfactants, through a "one step-reaction of a few seconds, it was possible to obtain sterilized nanoparticles to bind to insuline and eventually to other active biomolecules. The neuroprotective effects of NG-In, were tested on their ability to inhibit different neurodegenerative mechanisms (oxidative stress, mithocondrial disfunctions, cell death) induced by Abeta, a peptide involved in Alzheimer". The new bioengineered product was tested on its biocompatibility (lack of toxicity, proliferative immunogenic and thrombogenic activity) hemocompatibility and protection against protease.
The efficiency of NG-IN in passing through the Blood–Brain Barrier (BBB) was tested "in vitro" using a device for adhesion-dependent cell culture, with permeable inserts mimicking the natural barrier.






The insuline-conjugated nanogel (A), binds to the insuline receptor (B); it is biocompatible because it doesn't produce oxidative stress (C), mitochondrial disfunction (D) and apoptosis (E); NG-lN are able to go beyond the BBB (F).





Traduzione articolo: https://www.cnr.it/it/comunicato-stampa/6562/insulina-e-nanoparticelle-per-combattere-l-azheimer


Scritto da Chellee Mae Remacha Dela Reyna, Nisha Kumari| Articolo postato il 20-03-2018
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